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对苯二胺二盐酸盐

对苯二胺二盐酸盐用途

用作染料中间体

对苯二胺二盐酸盐名称

[ CAS 号 ]:
624-18-0

[ 中文名 ]:
对苯二胺盐酸盐

[ 英文名 ]:
Benzene-1,4-diammonium chloride

[中文别名 ]:

[英文别名 ]:

1,4-Benzenediamine dihydrochloride
Benzene-1,4-diamine dihydrochloride
EINECS 210-834-9
1,4-Benzenediamine, hydrochloride (1:2)
benzene-1,4-diamine,dihydrochloride
Benzol-1,4-diamindihydrochlorid
MFCD00013002

对苯二胺二盐酸盐物理化学性质

[ 密度 ]:
1.15 g/cm3

[ 沸点 ]:
267.4ºC at 760 mmHg

[ 熔点 ]:
>200°C

[ 分子式 ]:
C₆H₁₀Cl₂N₂

[ 分子量 ]:
181.063

[ 闪点 ]:
135.9ºC

[ 精确质量 ]:
180.022110

[ PSA ]:
52.04000

[ LogP ]:
3.61740

[ 外观性状 ]:
白色至粉红色固体

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
>=10 g/100 mL at 21 ºC

对苯二胺二盐酸盐MSDS

对苯二胺二盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ST0350000

CHEMICAL NAME :: p-Phenylenediamine, dihydrochloride

CAS REGISTRY NUMBER :: 624-18-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C6-H8-N2.2Cl-H

MOLECULAR WEIGHT :: 181.08

WISWESSER LINE NOTATION :: ZR DZ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 147 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 1250 ug/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12(Suppl 13),103,1988 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,125,1978

对苯二胺二盐酸盐安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H317-H319-H331-H410

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/24/25;R36;R43;R50/53

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S60-S61-S28A

[ 危险品运输编码 ]:
UN 1673 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
ST0350000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29215119

对苯二胺二盐酸盐合成路线

对苯二胺二盐酸盐上下游产品

对苯二胺二盐酸盐上游产品

对苯二胺二盐酸盐下游产品

对苯二胺二盐酸盐海关

[ 海关编码 ]: 2921519090

[ 中文概述 ]:
2921519090. 间-、对-苯二胺、二氨基甲苯等〔包括衍生物及它们的盐〕. 增值税率:17.0%. 退税率:17.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

对苯二胺二盐酸盐文献

Interaction of ceruloplasmin with eosinophil peroxidase as compared to its interplay with myeloperoxidase: Reciprocal effect on enzymatic properties.

Free Radic. Res. 49 , 800-11, (2015)

Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are involved in the development of halogenative stress during inflammation. We previously described a complex between MPO and ceruloplasmin (CP). ...

Development and validation of an LC-MS/MS method for determination of p-phenylenediamine and its metabolites in blood samples.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 997 , 1-6, (2015)

In some developing countries, p-phenylenediamine (PPD) is used in combination with Henna as hair dye or skin decoration. A sensitive LC-MS/MS method was developed and validated for the simultaneous de...

Quantitative risk assessment for skin sensitisation: consideration of a simplified approach for hair dye ingredients.

Regul Toxicol Pharmacol 64(3) , 459-65, (2012)

With the availability of the local lymph node assay, and the ability to evaluate effectively the relative skin sensitizing potency of contact allergens, a model for quantitative-risk-assessment (QRA) ...

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