| 常用名 | Mefuparib hydrochloride | CAS号 | 1449746-00-2 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively; displays >406-fold over other major nuclear PARPs including PARP3, TNKS1, TNKS2 and PARP6; reduces poly(ADP-ribose) formation, enhances γH2AX levels, induces G2/M arrest and subsequent apoptosis in homologous recombination repair (HR)-deficient cells; shows potent in vitro and in vivo proliferation and growth inhibition against HR-deficient cancer cells and synergistic sensitization of HR-proficient xenografts to the anticancer drug temozolomide. 物理化学性质: CAS号:1449746-00-2 常用中文名:Mefuparib hydrochloride 常用英文名:Mefuparib hydrochloride(CVL218) 分子式:C17H16ClFN2O2 分子量:334.775 密度:N/A 沸点:N/A 熔点:N/A 闪点:N/A 储存条件:-20°C,密闭,干燥 |