3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺
更新时间：2024-07-15 12:32:53
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| 常用名 | 3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺 | CAS号 | 174635-69-9 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier.IC50 Value: 4.4 nM ( Ki for hNK-3 receptor); 250 nM( Ki for hNK-2 receptor) [1]Target: NK3 Receptorin vitro: SB-222200 inhibited (125)I-[MePhe(7)]neurokinin B (NKB) binding to Chinese hamster ovary (CHO) cell membranes stably expressing the hNK-3 receptor (CHO-hNK-3R) with a K(i) = 4.4 nM and antagonized NKB-induced Ca(2+) mobilization in HEK 293 cells stably expressing the hNK-3 receptor (HEK 293-hNK-3R) with an IC(50) = 18.4 nM. SB-222200 was selective for hNK-3 receptors compared with hNK-1 (K(i) > 100,000 nM) and hNK-2 receptors (K(i) = 250 nM). n HEK 293 cells transiently expressing murine NK-3 receptors (HEK 293-mNK-3R), SB-222200 inhibited binding of (125)I-[MePhe(7)]NKB (K(i) = 174 nM) and antagonized NKB (1 nM)-induced calcium mobilization (IC(50) = 265 nM) [1].in vivo: In mice oral administration of SB-222200 produced dose-dependent inhibition of behavioral responses induced by i.p. or intracerebral ventricular administration of the NK-3 receptor-selective agonist, senktide, with ED(50) values of approximately 5 mg/kg. SB-222200effectively crossed the blood-brain barrier in the mouse and rat. The inhibitory effect of SB-222200 against senktide-induced behavioral responses in the mouse correlated significantly with brain, but not plasma, concentrations of the compound. Pharmacokinetic evaluation of SB-222200 in rat after oral administration (8 mg/kg) indicated sustained plasma concentrations (C(max) = about 400 ng/ml) and bioavailability of 46% [1]. 物理化学性质： CAS号：174635-69-9 常用中文名：3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺 常用英文名：SB-222200 分子式：C26H24N2O 分子量：380.48200 密度：1.142g/cm3 沸点：553.5ºC at 760 mmHg 熔点：N/A 闪点：288.6ºC 储存条件：2-8℃ |
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- 产品名：SB-222200
- 价格： ￥898.9/10mg ￥4668.9/250mg ￥2656.9/50mg ￥需询单/1g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺生产厂家
参考价格：$172/10mM*1mLinDMSO