MK2-IN-1盐酸盐
更新时间：2026-01-04 17:59:53
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| 常用名 | MK2-IN-1盐酸盐 | CAS号 | 1314118-94-9 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.IC50 value: 0.11 uM [1]Target: MAPKAPK2(MK2) inhibitorMK2-IN-1 was profiled for kinase selectivity by screening against a broad panel of 150 protein kinases at a concentration of 10 μM, and only CK1γ3 was significantly inhibited at greater than 50%. MK2-IN-1 inhibited pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion. MK2-IN-1 also dose dependently inhibited IL1β-stimulated matrixmetalloprotease (MMP)13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures. Of note, given its high degree of selectivity, our data suggest that MK2-IN-1 may be an excellent pharmacologic tool for specifically exploring and validating MK2 biology [3]. 物理化学性质： CAS号：1314118-94-9 常用中文名：MK2-IN-1盐酸盐 常用英文名：MK2-IN-1 (hydrochloride) 分子式：C27H26Cl2N4O2 分子量：509.427 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃ |
上海念兴实业有限公司
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- 产品名：MK2-IN-1 hydrochloride
- 价格： ￥8500.9/100mg ￥1200.9/10mg ￥650.9/5mg ￥4800.9/50mg
- 纯度：98.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$134/10mM*1mLinDMSO