MK2-IN-1盐酸盐

• 常用名: MK2-IN-1盐酸盐
• 英文名: MK2-IN-1 (hydrochloride)
• CAS号: 1314118-94-9
• 分子量: 509.427
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₆Cl₂N₄O₂
• 熔点: N/A
• 闪点: N/A

MK2-IN-1盐酸盐用途

MK2-IN-1盐酸盐是MAPKAPK2(MK2)激酶高效选择性抑制剂,IC50值0.11uM。

MK2-IN-1盐酸盐名称

• 中文名: MK2-IN-1盐酸盐
• 英文名: MK 25 (hydrochloride)

MK2-IN-1盐酸盐生物活性

• 描述: MK2-IN-1盐酸盐是MAPKAPK2(MK2)激酶高效选择性抑制剂,IC50值0.11uM。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> MAPKAPK2(MK2)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Rao AU, et al. Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.

  [2]. Huang X, et al. A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.

  [3]. Huang X, et al. Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.

MK2-IN-1盐酸盐物理化学性质

• 分子式: C₂₇H₂₆Cl₂N₄O₂
• 分子量: 509.427
• 精确质量: 508.143280
• PSA: 61.61000
• LogP: 6.44740
• InChIKey: AZDOSXSDARWKGX-UHFFFAOYSA-N
• SMILES: Cl.O=C(c1ccc(-c2ccc(Cl)cc2)o1)N(Cc1ccccn1)c1ccc(N2CCNCC2)cc1
• 储存条件: 2-8℃

MK2-IN-1盐酸盐英文别名

• 2-Furancarboxamide, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-, hydrochloride (1:1)
• 5-(4-Chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furamide hydrochloride (1:1)
• MK2-IN-1 (hydrochloride)