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薯蓣皂甙

更新时间:2024-09-16 17:24:49

常用名 薯蓣皂甙;薯蓣皂苷 CAS号 19057-60-4
价格 ¥35000.0/1kg ¥400.0/1g 纯度 98.0%
备货期 需询单 库存 现货
 产品详情(用途,包装等)
用途:
Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. IC50 value:Target: Anticancer agentin vitro: dioscin (1, 2 and 4 μmol/L) could significantly inhibit the viability of LNCaP cells in a time- and concentration-dependent manner. Flow cytometry revealed that the apoptosis rate was increased after treatment of LNCaP cells with dioscin for 24 h, indicating that apoptosis was an important mechanism by which dioscin inhibited cancer [1]. dioscin abrogated AKT phosphorylation, which subsequently impaired RANKL-induced nuclear factor-kappaB (NF-κB) signaling pathway and inhibited NFATc1 transcriptional activity. Moreover, in vivo studies further verified the bone protection activity of dioscin in osteolytic animal model [2]. Dioscin reduced cell death and lactate dehydrogenase (LDH) release in cells subjected to I/R. I/R induced apoptosis and cytochrome c release from mitochondria to the cytosol and this was prevented by dioscin. In support, dioscin decreased Bax but increased Bcl-2 mRNA expression. Dioscin prevented I/R induced dissipation of ΔΨm [3].
物理化学性质:
CAS号:19057-60-4
常用中文名:薯蓣皂甙;薯蓣皂苷
常用英文名:Dioscin
分子式:C45H72O16
分子量:869.044
密度:1.4±0.1 g/cm3
沸点:N/A
熔点:294-296 ℃
闪点:N/A
储存条件:室温

供应商信息

杨凌慈缘生物技术有限公司

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地址:丰登南路2号
地区: 陕西省 西安市 莲湖区
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参考价格:$76/10mM*1mLinDMSO
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