Organic letters

Practical synthesis of phthalimides and benzamides by a multicomponent reaction involving arynes, isocyanides, and CO2/H2O

T Kaicharla, M Thangaraj, AT Biju

文献索引：Kaicharla, Trinadh; Thangaraj, Manikandan; Biju, Akkattu T. Organic Letters, 2014 , vol. 16, # 6 p. 1728 - 1731

被引用次数: 22

摘要

Transition-metal-free multicomponent reactions involving arynes and isocyanides with either CO2 or H2O have been reported. With CO2 as the third component, the reactions resulted in the formation of N-substituted phthalimides. The utility of water as the third component furnished benzamide derivatives in moderate to good yields. These reactions took place under mild conditions with broad scope.

~70%

~76%

~25%

~62%

~62%

~52%

~80%

~85%

~68%

~80%

~82%

~43%

~55%

~47%

~57%

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