Tetrahedron Letters

Solvent free, N, N′-carbonyldiimidazole (CDI) mediated amidation

SK Verma, R Ghorpade, A Pratap, MP Kaushik

文献索引：Verma, Sanjeev K.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2373 - 2376

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被引用次数: 21

摘要

The method involves CDI mediated amidation under solvent-free conditions. The protocol is green, simple, and scalable and has broad structural applicability. The protocol has also been used for BOC protection of amine. The protocol has reduced the time for CDI mediated amidation from 2–4h to 5–10min without the use of any dry organic solvent and nitrogen atmosphere.