Electron deficiency of aldehydes controls the pyrrolidine catalyzed direct cross-aldol reaction of aromatic/heterocyclic aldehydes and ketones in water
The aldol reaction constitutes a fundamental synthetic methodology for forming carbon–carbon bonds and nature itself seems to prefer this reaction in its biosynthetic processes, for example, in the prebiotic formation of saccharides. 1 The reaction is typically catalyzed by aldolases (Class I and Class II) for direct aldolization of two unmodified carbonyl compounds. Synthetic methodologies involving both aldolase 2 and catalytic antibodies 3 have been ...
