TMEDA-Assisted Effective Direct Ortho Arylation of Electron-Deficient N-Heteroarenes with Aromatic Grignard Reagents

…, WW Xie, YX Yang, L Zhang, P Wang…

文献索引：Zhang, Fang; Zhang, Song; Duan, Xin-Fang Organic Letters, 2012 , vol. 14, # 21 p. 5618 - 5620

全文：HTML全文

被引用次数: 17

摘要

In the addition of TMEDA in toluene, aryl Grignards could effectively and site-specifically ortho-arylate electron-deficient heteroarenes under mild conditions. This endeavor successfully changed the old low-yielding reaction, aryl Grignard addition to N-