A general method for copper-catalyzed arylation of arene C− H bonds

HQ Do, RMK Khan, O Daugulis

文献索引：Do, Hien-Quang; Khan, Rana M. Kashif; Daugulis, Olafs Journal of the American Chemical Society, 2008 , vol. 130, # 45 p. 15185 - 15192

全文：HTML全文

被引用次数: 421

摘要

A general method for copper-catalyzed arylation of sp2 C− H bonds with p K aʼs below 35 has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide or K3PO4 base, and DMF, DMPU, or mixed DMF/xylenes solvent. A variety of electron-rich and electron-poor heterocycles such as azoles, caffeine, thiophenes, benzofuran, pyridine oxides, pyridazine, and pyrimidine can be arylated. Furthermore, ...