TMEDA-Assisted Effective Direct Ortho Arylation of Electron-Deficient N-Heteroarenes with Aromatic Grignard Reagents

…, WW Xie, YX Yang, L Zhang, P Wang…

Index: Zhang, Fang; Zhang, Song; Duan, Xin-Fang Organic Letters, 2012 , vol. 14, # 21 p. 5618 - 5620

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Citation Number: 17

Abstract

In the addition of TMEDA in toluene, aryl Grignards could effectively and site-specifically ortho-arylate electron-deficient heteroarenes under mild conditions. This endeavor successfully changed the old low-yielding reaction, aryl Grignard addition to N-

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