Development of a Practical and Convergent Process for the Preparation of Sulopenem

…, E Chisowa, MP Delude, MT Drexler…

文献索引：Brenek, Steven J.; Caron, Stephane; Chisowa, Esmort; Delude, Mark P.; Drexler, Michele T.; Ewing, Marcus D.; Handfield, Robert E.; Ide, Nathan D.; Nadkarni, Durgesh V.; Nelson, Jade D.; Olivier, Mark; Perfect, Hahdi H.; Phillips, James E.; Teixeira, John J.; Weekly, R. Matt; Zelina, John P. Organic Process Research and Development, 2012 , vol. 16, # 8 p. 1348 - 1359

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被引用次数: 3

摘要

Previous synthetic processes for the preparation of sulopenem involved multistep linear sequences in which the chiral sulfoxide side chain was introduced early in the process. This contribution summarizes the development of a practical and convergent process for the large-scale preparation of 1. The key step in the synthesis involves cyclization of an oxalimide intermediate to provide the thiopenem core. This convergent strategy allows for ...