Development of a Practical and Convergent Process for the Preparation of Sulopenem

…, E Chisowa, MP Delude, MT Drexler…

Index: Brenek, Steven J.; Caron, Stephane; Chisowa, Esmort; Delude, Mark P.; Drexler, Michele T.; Ewing, Marcus D.; Handfield, Robert E.; Ide, Nathan D.; Nadkarni, Durgesh V.; Nelson, Jade D.; Olivier, Mark; Perfect, Hahdi H.; Phillips, James E.; Teixeira, John J.; Weekly, R. Matt; Zelina, John P. Organic Process Research and Development, 2012 , vol. 16, # 8 p. 1348 - 1359

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Citation Number: 3

Abstract

Previous synthetic processes for the preparation of sulopenem involved multistep linear sequences in which the chiral sulfoxide side chain was introduced early in the process. This contribution summarizes the development of a practical and convergent process for the large-scale preparation of 1. The key step in the synthesis involves cyclization of an oxalimide intermediate to provide the thiopenem core. This convergent strategy allows for ...