Tetrahedron: Asymmetry

Lipase-mediated asymmetric construction of 2-arylpropionic acids: enantiocontrolled syntheses of S-naproxen and S-ibuprofen

T Bando, Y Namba, K Shishido

文献索引：Bando, Toshikazu; Namba, Yukiko; Shishido, Kozo Tetrahedron Asymmetry, 1997 , vol. 8, # 13 p. 2159 - 2165

被引用次数: 35

摘要

A general and enantiocontrolled synthetic route to 2-arylpropionic acids, represented by non- steroidal anti-inflammatory drugs S-naproxen 1a and S-ibuprofen 1b, has been developed by employing the lipase-mediated asymmetric acetylation of prochiral 2-aryl-1, 3- propanediol 3, which has been derived via a Heck reaction, as the key step.

~77%

查看详情

~99%

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

~83%

查看详情

~99%

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

查看详情

Use of a Robust Dehydrogenase from an Archael Hyperthermophi...

[Friest, Jacob A.; Maezato, Yukari; Broussy, Sylvain; Blum, Paul; Berkowitz, David B. Journal of the American Chemical Society, 2010 , vol. 132, # 17 p. 5930 - 5931]

Asymmetric dihydroxylation in an approach to the enantiosele...

[Griesbach, Robert C.; Hamon, David P. G.; Kennedy, Rebecca J. Tetrahedron Asymmetry, 1997 , vol. 8, # 4 p. 507 - 510]

Reduction of carbonyl compounds with polyethylsiloxane in th...

[Kozhukhova; Yatluk; Suvorov; Koryakova Russian Journal of Organic Chemistry, 2004 , vol. 40, # 6 p. 759 - 762]

Parallel kinetic resolution of 1-phenylethanol using quasi-e...

[Coulbeck, Elliot; Eames, Jason Synlett, 2008 , # 3 p. 333 - 338]

Regio-and enantiocontrol in the room-temperature hydroborati...

[Crudden, Cathleen M.; Hleba, Yonek B.; Chen, Austin C. Journal of the American Chemical Society, 2004 , vol. 126, # 30 p. 9200 - 9201]