Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis− Dynamic Reductive Kinetic Resolution Entry into (S)-Profens

JA Friest, Y Maezato, S Broussy, P Blum…

文献索引：Friest, Jacob A.; Maezato, Yukari; Broussy, Sylvain; Blum, Paul; Berkowitz, David B. Journal of the American Chemical Society, 2010 , vol. 132, # 17 p. 5930 - 5931

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被引用次数: 42

摘要

Described is an efficient heterologous expression system for Sulfolobus solfataricus ADH-10 (Alcohol Dehydrogenase isozyme 10) and its use in the dynamic reductive kinetic resolution (DYRKR) of 2-arylpropanal (Profen-type) substrates. Importantly, among the 12 aldehydes tested, a general preference for the (S)-antipode was observed, with high ee's for substrates corresponding to the NSAIDs (nonsteroidal anti-inflammatory drugs) naproxen, ibuprofen, ...