Organic letters

Rapid and efficient microwave-assisted amination of electron-rich aryl halides without a transition-metal catalyst

L Shi, M Wang, CA Fan, FM Zhang, YQ Tu

文献索引：Shi, Lei; Wang, Min; Fan, Chun-An; Zhang, Fu-Min; Tu, Yong-Qiang Organic Letters, 2003 , vol. 5, # 19 p. 3515 - 3517

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被引用次数: 125

摘要

A rapid and direct amination of aryl halides has been developed in good to high yields under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, the excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines from ortho-or para-substituted phenylhalides. In addition, a ...