A novel, safe, and robust nitration process for the synthesis of 4-(4-methoxy-3-nitrophenyl) morpholine

P Zhang, A Shankar, TP Cleary…

文献索引：Pingsheng, Zhang; Shankar, Ashish; Cleary, Thomas P.; Cedilote, Miall; Locklear, Dobbert; Pierce, Michael E. Organic Process Research and Development, 2007 , vol. 11, # 5 p. 861 - 864

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被引用次数: 3

摘要

A novel nitration process was developed for the production of 4-(4-methoxy-3-nitrophenyl) morpholine. Crude 4-(4-methoxyphenyl) morpholine produced in step 1 was converted to its nitric acid salt. The nitration reaction was carried out by adding a dichloromethane solution of the isolated salt to concentrated sulfuric acid. This protocol provided an easy and reliable way to obtain a 1: 1 molar ratio of the substrate and nitric acid in the reaction mixture and ...