Tetrahedron letters

Efficient one-pot synthesis of anti HIV and antitumor compounds: harman and substituted harmans

RS Kusurkar, SK Goswami, SM Vyas

文献索引：Kusurkar, Radhika S.; Goswami, Shailesh K.; Vyas, Sandhya M. Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4761 - 4763

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被引用次数: 39

摘要

The β-carboline ring system is present in many naturally occurring alkaloids which exhibit 1 interesting biological activities. Harman 9 has been reported 2 to show mutagenic and co-mutagenic properties and to inhibit topoisomerase I. Harmine 12 showed 2 significant antitumor activity. Recently harman, harmine and their derivatives were shown 3 to possess potent anti HIV activity. ... Amongst the variety of methods available for the synthesis of β-carboline alkaloids, the most ...