Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere.

T Mimoto, N Hattori, H Takaku, S Kisanuki…

文献索引：Chemical and Pharmaceutical Bulletin, , vol. 48, # 9 p. 1310 - 1326

全文：HTML全文

被引用次数: 44

摘要

... 3). © 2000 Pharmaceutical Society of Japan NIT—Electronic Library Service ... 1. Chemical Structures ofKNl—227, —272, and JE-2178, -2179 1311 R2 = Me : JE-2178 (24g) R2 ... Chemistry Boc—Apns—OH (1a), and Boc—Pns—OH (1b) were prepared according to the methods ...