Synthetic Anticonvulsants. The Preparation and Properties of Some Benzoxazoles1

WG Bywater, WR Coleman, O Kamm…

文献索引：Bywater et al. Journal of the American Chemical Society, 1945 , vol. 67, p. 905

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被引用次数: 50

摘要

There is some evidence that in certain series of compounds having hypnotic activity, higher molecular weight members possess anticonvulsant activity without inducing a hypnotic effect, ie, the change from 5-phenyl-5-ethylhydantoin to dilantin (5, 5-diphenylhydantoin) resulted in a greatly increased convulsive threshold and no hypnotic effect. This observation prompted us to investigate the benzoxazoles for three reasons. First, benzoxazolone (2- ...