Novel diarylheptanoids as inhibitors of TNF-α production

S Dhuru, D Bhedi, D Gophane, K Hirbhagat…

文献索引：Dhuru, Sameer; Bhedi, Dilip; Gophane, Dnyaneshwar; Hirbhagat, Kiran; Nadar, Vijaya; More, Dattatray; Parikh, Sapna; Dalal, Roda; Fonseca, Lyle C.; Kharas, Firuza; Vadnal, Prashant Y.; Vishwakarma, Ram A.; Sivaramakrishnan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3784 - 3787

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被引用次数: 9

摘要

Abstract Synthesis and anti-inflammatory activity of novel diarylheptanoids [5-hydroxy-1- phenyl-7-(pyridin-3-yl)-heptan-3-ones and 1-phenyl-7-(pyridin-3-yl) hept-4-en-3-ones] as inhibitors of tumor necrosis factor-α (TNF-α) production is described in the present article. The key reactions involve the formation of a β-hydroxyketone by the reaction of substituted 4- phenyl butan-2-ones with pyridine-3-carboxaldehyde in presence of LDA and the ...