Tetrahedron

Synthesis of diastereomeric, deoxy and ring-expanded sulfone analogues of aigialomycin D

…, A Chan, JH Miller, PH Teesdale-Spittle, JE Harvey

文献索引：Ting, Samuel Z.Y.; Baird, Lynton J.; Dunn, Elyse; Hanna, Reem; Leahy, Dora; Chan, Ariane; Miller, John H.; Teesdale-Spittle, Paul H.; Harvey, Joanne E. Tetrahedron, 2013 , vol. 69, # 49 p. 10581 - 10592

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被引用次数: 6

摘要

Abstract Several analogues of the fungal natural product aigialomycin D (AmD) have been synthesised. These include the stereoisomer 5′ R, 6′ S-AmD, 2, 4-di-deoxyAmD, 1′, 2′, 7′, 8′-tetrahydroAmD and a 15-membered macrocyclic sulfone. Growth inhibitory activities of these compounds against the HL-60 leukaemic cell line were measured. The ring-expanded sulfone and tetrahydro-analogue were found to have similar IC 50 values ...