Tetrahedron

Efficient tetrahydropyranyl and tetrahydrofuranyl protection/deprotection of alcohols and phenols with Al (OTf) 3 as catalyst

DBG Williams, SB Simelane, M Lawton, HH Kinfe

文献索引：Williams, D. Bradley G.; Simelane, Sandile B.; Lawton, Michelle; Kinfe, Henok H. Tetrahedron, 2010 , vol. 66, # 25 p. 4573 - 4576

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被引用次数: 33

摘要

A simple and efficient method for the conversion of alcohols and phenols into their corresponding THP and THF ethers at room temperature has been developed using 1mol% aluminium triflate as catalyst. The deprotection reaction in the presence of methanol using Al (OTf) 3 was equally successful and could be performed at ambient temperature in high yields.