Tetrahedron

A mild robust generic protocol for the Suzuki reaction using an air stable catalyst

JD Moseley, PM Murray, ER Turp, SNG Tyler, RT Burn

文献索引：Moseley, Jonathan D.; Murray, Paul M.; Turp, Edward R.; Tyler, Simon N.G.; Burn, Ross T. Tetrahedron, 2012 , vol. 68, # 30 p. 6010 - 6017

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被引用次数: 16

摘要

A mild but robust procedure has been developed as a first pass generic protocol for the Suzuki–Miyaura reaction. The protocol employs an air stable palladium pre-catalyst at low loading (≤ 1mol%) in aqueous solvent mixtures at moderate temperature using potassium carbonate as base. Under these mild conditions, most aryl bromides will react with sterically and electronically demanding aryl boronic acids to give complete conversion to the ...