Palladium (0)??Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl and Alkenyl Boronic …

I Ban, A Nonoyama, K Sumi, C Kuang…

文献索引：Doi, Hisashi; Ban, Ikuya; Nonoyama, Akihito; Sumi, Kengo; Kuang, Chunxiang; Hosoya, Takamitsu; Tsukada, Hideo; Suzuki, Masaaki Chemistry - A European Journal, 2009 , vol. 15, # 16 p. 4165 - 4171

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被引用次数: 45

摘要

Abstract A new synthetic methodology for the rapid methylation and fluoromethylation on aryl and alkenyl frameworks by using methyl and fluoromethyl iodide with an organoboronic acid ester has been developed under the simple and mild conditions of [Pd 2 (dba) 3]/P (o- CH 3 C 6 H 4) 3/K 2 CO 3 (dba= dibenzylideneacetone) in DMF at 60 C for 5 min (see scheme). This boron protocol provides a firm chemical basis for the synthesis of 11 C-and ...