Palladium (0)??Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl and Alkenyl Boronic …

I Ban, A Nonoyama, K Sumi, C Kuang…

Index: Doi, Hisashi; Ban, Ikuya; Nonoyama, Akihito; Sumi, Kengo; Kuang, Chunxiang; Hosoya, Takamitsu; Tsukada, Hideo; Suzuki, Masaaki Chemistry - A European Journal, 2009 , vol. 15, # 16 p. 4165 - 4171

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Citation Number: 45

Abstract

Abstract A new synthetic methodology for the rapid methylation and fluoromethylation on aryl and alkenyl frameworks by using methyl and fluoromethyl iodide with an organoboronic acid ester has been developed under the simple and mild conditions of [Pd 2 (dba) 3]/P (o- CH 3 C 6 H 4) 3/K 2 CO 3 (dba= dibenzylideneacetone) in DMF at 60 C for 5 min (see scheme). This boron protocol provides a firm chemical basis for the synthesis of 11 C-and ...