Tetrahedron

Studies on pyrrolidinones. On the application of copper-catalyzed arylation of methyl pyroglutamate to obtain a new benzo [de] quinoline scaffold

…, S Oudir, JP Hénichart, B Rigo, N Pommery, P Gautret

文献索引：Ghinet, Alina; Oudir, Souhila; Henichart, Jean-Pierre; Rigo, Benoit; Pommery, Nicole; Gautret, Philippe Tetrahedron, 2010 , vol. 66, # 1 p. 215 - 221

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被引用次数: 9

摘要

Optimized conditions for copper-catalyzed N-arylation of methyl pyroglutamate are described. These studies permitted the synthesis of methyl N-naphthylpyroglutamate, which was then cyclized to a ketone. The known dehydration of amidoketones by PPA was extended to this new scaffold to lead to a novel condensed benzo [de] quinoline with potential antioxidative activity.