Biomaterials 2015-05-01

Enhanced osteointegration on tantalum-implanted polyetheretherketone surface with bone-like elastic modulus.

Tao Lu, Jin Wen, Shi Qian, Huiliang Cao, Congqin Ning, Xiaoxia Pan, Xinquan Jiang, Xuanyong Liu, Paul K Chu

文献索引：Biomaterials 51 , 173-83, (2015)

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摘要

Polyetheretherketone (PEEK) possesses a similar elastic modulus as bones but yet suffers from bio-inertness and poor osteogenesis. In this work, tantalum ions are implanted energetically into PEEK by plasma immersion ion implantation (PIII) to form Ta2O5 nanoparticles in the near surface. Nanoindentation reveals that the surface elastic modulus of the Ta ion implanted PEEK is closer to that of human cortical bones. In vitro cell adhesion, alkaline phosphatase activity, collagen secretion, extracellular matrix mineralization, and real-time PCR analyses disclose enhanced adhesion, proliferation, and osteogenic differentiation of rat bone mesenchymal stem cells (bMSCs) on the Ta-PIII modified PEEK. In vivo evaluation of the cortico-cancellous rat femur model by means of micro-CT, sequential fluorescent labeling, and histological analysis after 8 weeks confirms significantly improved osteointegration. The bone-like elastic modulus and modified surface topography of the Ta-PIII modified PEEK synergistically induce osteogenic differentiation of bMSCs and the surface-modified materials have large potential in dental and orthopedic implants.Copyright © 2015 Elsevier Ltd. All rights reserved.