前往化源商城

Neuropharmacology 2015-04-01

Activation of serotonin2A receptors in the medial septum-diagonal band of Broca complex enhanced working memory in the hemiparkinsonian rats.

Li-Bo Li, Li Zhang, Yi-Na Sun, Ling-Na Han, Zhong-Heng Wu, Qiao-Jun Zhang, Jian Liu

文献索引:Neuropharmacology 91 , 23-33, (2015)

全文:HTML全文

摘要

Serotonin2A (5-HT2A) receptors are highly expressed in the medial septum-diagonal band of Broca complex (MS-DB), especially in parvalbumin (PV)-positive neurons linked to hippocampal theta rhythm, which is involved in cognition. Cognitive impairments commonly occur in Parkinson's disease. Here we performed behavioral, electrophysiological, neurochemical and immunohistochemical studies in rats with complete unilateral 6-hydroxydopamine lesions of the medial forebrain bundle (MFB) to assess the importance of dopamine (DA) depletion and MS-DB 5-HT2A receptors for working memory. The MFB lesions resulted in working memory impairment and decreases in firing rate and density of MS-DB PV-positive neurons, peak frequency of hippocampal theta rhythm, and DA levels in septohippocampal system and medial prefrontal cortex (mPFC) compared to control rats. Intra-MS-DB injection of high affinity 5-HT2A receptor agonist TCB-2 enhanced working memory, increased firing rate of PV-positive neurons and peak frequency of hippocampal theta rhythm, elevated DA levels in the hippocampus and mPFC, and decreased 5-HT level in the hippocampus in control and lesioned rats. Compared to control rats, the duration of the excitatory effect produced by TCB-2 on the firing rate of PV-positive neurons was markedly shortened in lesioned rats, indicating dysfunction of 5-HT2A receptors. These findings suggest that unilateral lesions of the MFB in rats induced working memory deficit, and activation of MS-DB 5-HT2A receptors enhanced working memory, which may be due to changes in the activity of septohippocampal network and monoamine levels in the hippocampus and mPFC. Copyright © 2014 Elsevier Ltd. All rights reserved.

相关化合物

结构式 名称/CAS号 全部文献
磷酸二氢钠单水合物 结构式 磷酸二氢钠单水合物
CAS:10049-21-5
盐酸 结构式 盐酸
CAS:7647-01-0
乙腈 结构式 乙腈
CAS:75-05-8
磷酸 结构式 磷酸
CAS:7664-38-2
荧光素 结构式 荧光素
CAS:2321-07-5
1-辛基磺酸钠 结构式 1-辛基磺酸钠
CAS:5324-84-5
三乙胺 结构式 三乙胺
CAS:121-44-8
乙二胺四乙酸 结构式 乙二胺四乙酸
CAS:60-00-4
去甲丙咪嗪盐酸盐 结构式 去甲丙咪嗪盐酸盐
CAS:58-28-6
阿朴吗啡 结构式 阿朴吗啡
CAS:41372-20-7