Hydroxynitrile lyases from almond and sorghum as biocatalysts

…, GJM Van Scharrenburg, JB Sloothaak

文献索引：Smitskamp-Wilms, E.; Brusse, J.; Gen, A. van der; Scharrenburg, G.J.M. van; Sloothaak, J. B. Recueil des Travaux Chimiques des Pays-Bas, 1991 , vol. 110, # 5 p. 209 - 215

全文：HTML全文

被引用次数: 54

摘要

Abstract Hydroxynitrile lyases from sweet almond (EC 4.1. 2.10) and from sorghum bicolor (EC 4.1. 2.11) have been purified to homogeneity by ion-exchange chromatography. These enzymes catalyse the decomposition of α-hydroxynitriles to aldehydes and hydrocyanic acid (HCN) and show great promise for synthetic applications in the reverse reaction: the stereospecific addition of HCN to aldehydes to form enantio-pure α-hydroxynitriles.

~90%

~87%

~88%

Sc (BINOL) 2 Li: a new heterobimetallic catalyst for the asy...

[Chavarot, Murielle; Byrne, Janice J.; Chavant, Pierre Y.; Vallee, Yannick Tetrahedron Asymmetry, 2001 , vol. 12, # 8 p. 1147 - 1150]

Cyanobenzoylation and hydrocyanation of aldehydes with benzo...

[Watahiki, Tsutomu; Ohba, Sayoko; Oriyama, Takeshi Organic Letters, 2003 , vol. 5, # 15 p. 2679 - 2681]

Indium-mediated reductive dehalogenation of α-halocarbonyl c...

[Park, Leeyoung; Keum, Gyochang; Kang, Soon Bang; Kim, Kwan Soo; Kim, Youseung Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 24 p. 4462 - 4463]

Dibutyltin Dimethoxide??Catalyzed Cyano Transfer to Aldehyde...

[Yanagisawa, Akira; Matsumoto, Takuya; Kushihara, Naoyuki; Yoshida, Kazuhiro Advanced Synthesis and Catalysis, 2010 , vol. 352, # 17 p. 2918 - 2922]

Synthesis of α-aminoketones via selective reduction of acyl ...

[Pfaltz, Andreas; Anwar, Saeed Tetrahedron Letters, 1984 , vol. 25, # 28 p. 2977 - 2980]