Hydroxynitrile lyases from almond and sorghum as biocatalysts

…, GJM Van Scharrenburg, JB Sloothaak

Index: Smitskamp-Wilms, E.; Brusse, J.; Gen, A. van der; Scharrenburg, G.J.M. van; Sloothaak, J. B. Recueil des Travaux Chimiques des Pays-Bas, 1991 , vol. 110, # 5 p. 209 - 215

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Citation Number: 54

Abstract

Abstract Hydroxynitrile lyases from sweet almond (EC 4.1. 2.10) and from sorghum bicolor (EC 4.1. 2.11) have been purified to homogeneity by ion-exchange chromatography. These enzymes catalyse the decomposition of α-hydroxynitriles to aldehydes and hydrocyanic acid (HCN) and show great promise for synthetic applications in the reverse reaction: the stereospecific addition of HCN to aldehydes to form enantio-pure α-hydroxynitriles.

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