European Journal of Organic Chemistry

Asymmetric Copper (II)??Catalysed Nitroaldol (Henry) Reactions Utilizing a Chiral C1??Symmetric Dinitrogen Ligand

Y Zhou, Y Gong

文献索引：Zhou, Yirong; Gong, Yuefa European Journal of Organic Chemistry, 2011 , # 30 p. 6092 - 6099

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被引用次数: 12

摘要

Abstract A series of stable chiral C 1-symmetric dinitrogen ligands were conveniently synthesized in high yields by condensation of chiral amines [(–)-exo-bornylamine or (+)-(1S, 2S, 5R)-menthylamine] with various substituted imidazolecarbaldehydes. With the assistance of base, the ligand L1 in combination with CuCl 2· 2H 2 O (2.5 mol-% or 5.0 mol- %) can efficiently promote nitroaldol (Henry) reactions between a variety of aldehydes and ...