Synthesis and biological evaluation of novel 2-(2-arylmethylene) hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents

…, X Zhai, Y Zhao, Y Liu, B Qi, H Tao, P Gong

文献索引：Jiang, Nan; Zhai, Xin; Zhao, Yanfang; Liu, Yajing; Qi, Baohui; Tao, Haiyan; Gong, Ping European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 534 - 541

全文：HTML全文

被引用次数: 11

摘要

Two series of novel 2-(2-arylmethylene) hydrazinyl-4-aminoquinazoline derivatives were synthesized and evaluated for their cytotoxicity against H-460, HT-29, HepG2 and SGC- 7901 cancer cell lines in vitro. Most compounds displayed moderate to excellent activity, with IC50 values ranging from 0.015 to 4.09 μM against all tested cell lines, respectively. The most promising compound 9p (E)-2-(2-((1-(2, 3-dichlorobenzyl)-1H-imidazol-2-yl) ...