Process improvements for the manufacture of tenofovir disoproxil fumarate at commercial scale

DH Brown Ripin, DS Teager, J Fortunak…

文献索引：Organic Process Research and Development, , vol. 14, # 5 p. 1194 - 1201

被引用次数: 35

摘要

... Organic Process Research & Development. ... Two practical alternatives to TMSBr for the execution of this process are available. Either aqueous HBr(7) or the use of TMSCl in the presence of NaBr in organic solvent(6) was preferred for process stage 2b. ...