Tetrahedron letters

Facile removal of new base protecting groups useful in oligonucleotide synthesis

JC Schulhof, D Molko, R Teoule

文献索引：Schulhof, J. C.; Molko, D.; Teoule, R. Tetrahedron Letters, 1987 , vol. 28, # 1 p. 51 - 54

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被引用次数: 57

摘要

Abstract New base protecting groups are proposed in place of benzoyl and isobutyryl groups. They are phenoxy acetyl for adenine and guanine and isobutyryl for cytosine. They are cleaved in aqueous ammonia in a shorter time at lower temperature. These easily removable groups are useful in the synthesis of modified oligonucleotides, containing fragile bases.