Bioorganic & medicinal chemistry letters

Polymer supported carbodiimide strategy for the synthesis of N-acylated derivatives of deoxy-and ribo purinenucleosides using active esters

S Tripathi, K Misra, YS Sanghvi

文献索引：Tripathi, Snehlata; Misra, Krishna; Sanghvi, Yogesh S. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 5045 - 5048

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被引用次数: 6

摘要

A cost-effective synthetic strategy has been used for the selective protection of the exocyclic amino function of purine nucleosides. Instead of using the common protecting groups in their chloride or anhydride forms, the less expensive and nontoxic acidic form was chosen. The acids were first activated to an active ester form using DCC and further successfully used for N-acylation of purine nucleosides. The contamination of the N-acylated product with DCU ...