A practical synthesis of m-prostaglandin E synthase-1 inhibitor MK-7285

F Gosselin, S Lau, C Nadeau, T Trinh…

文献索引：Chassaing, Christophe; Haudrechy, Arnaud; Langlois, Yves Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4415 - 4416

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被引用次数: 22

摘要

... Volume: Page: ... Synthesis of Aldehyde 23. End-Game Chemistry Condensation of phenanthrene diketone 2 with 2,6-dibromo-4-fluorobenzaldehyde 23 in the presence of ammonium acetate in AcOH for 1 h at 90 °C afforded dibromoimidazole 25 in 85% yield ...