Carboxylation of kinetically inert platinum (IV) hydroxy complexes. An Entr. acte. ee into orally active platinum (IV) antitumor agents
CM Giandomenico, MJ Abrams, BA Murrer…
文献索引：Giandomenico, Christen M.; Abrams, Michael J.; Murrer, Barry A.; Vollano, Jean F.; Rheinheimer, Melanie I.; et al. Inorganic Chemistry, 1995 , vol. 34, p. 1015 - 1021
Carboxylation of hydroxide coordinated to Pt (1V) by anhydrides, pyrocarbonates, and isocyanates to form the corresponding Pt (1V) carboxylates, carbonates, and carbamates is described. For example, the acylation with acetic anhydride of (OC-6-33)-amminedichloro (cyclohexanamine) dihydroxyplatinum (IV) leads to formation of (OC-6-43)-bis (acetato-O) amminedichloro (cyclohexanamine) platinum (IV)(JM-216) in 60% yield. This compound is ...
