Crystal and molecular structures of asymmetric cis-and trans-platinum (II/IV) compounds and their reactions with DNA fragments

…, W Brüning, J Reedijk, AL Spek, N Veldman

文献索引：Talman, Eduard G.; Bruening, Wolfgang; Reedijk, Jan; Spek, Anthony L.; Veldman, Nora Inorganic Chemistry, 1997 , vol. 36, # 5 p. 854 - 861

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被引用次数: 119

摘要

The crystal structures of cis-Pt (NH3)(c-C6H11NH2) Cl2 and trans-Pt (NH3)(c-C6H11NH2) Cl2 are described as well as their reactions with 9-methylhypoxanthine and 5'-GMP. Related Platinum (IV) bis (carboxylate) complexes result in similar Pt (II)-DNA adducts as the major products. However, trans, trans, trans-Pt (NH3)(c-C6H11NH2) Cl2 (OH) 2 reacts only when a reducing agent like glutathione is present.