Carboxylation of kinetically inert platinum (IV) hydroxy complexes. An Entr. acte. ee into orally active platinum (IV) antitumor agents

CM Giandomenico, MJ Abrams, BA Murrer…

Index: Giandomenico, Christen M.; Abrams, Michael J.; Murrer, Barry A.; Vollano, Jean F.; Rheinheimer, Melanie I.; et al. Inorganic Chemistry, 1995 , vol. 34, p. 1015 - 1021

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Citation Number: 224

Abstract

Carboxylation of hydroxide coordinated to Pt (1V) by anhydrides, pyrocarbonates, and isocyanates to form the corresponding Pt (1V) carboxylates, carbonates, and carbamates is described. For example, the acylation with acetic anhydride of (OC-6-33)-amminedichloro (cyclohexanamine) dihydroxyplatinum (IV) leads to formation of (OC-6-43)-bis (acetato-O) amminedichloro (cyclohexanamine) platinum (IV)(JM-216) in 60% yield. This compound is ...