Abstract Treatment of 6-acetyl-5-amino-4-methyl-2-phenylthieno [2, 3-d] pyrimidine 3 with 2, 5-dimethoxytetra-hydrofuran afforded the 6-acetyl-5-(1-pyrrolyl)-4-methyl-2-phenylthieno [2, 3-d] pyrimidine 4, which can react with appropriate primary amines 5a-f to yield the corresponding Schiffs base derivatives 6a-f. The reaction of acetyl compound 4 with appropriate arylaldehydes 14a-k and arylmethylidenemalononitriles 18a-f afforded the ...