Structural Analysis of ATP Analogues Compatible with Kinase-Catalyzed Labeling

S Suwal, C Senevirathne, S Garre…

文献索引：Suwal, Sujit; Senevirathne, Chamara; Garre, Satish; Pflum, Mary Kay H. Bioconjugate Chemistry, 2012 , vol. 23, # 12 p. 2386 - 2391

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被引用次数: 9

摘要

Kinase-catalyzed protein phosphorylation is an important biochemical process involved in cellular functions. We recently discovered that kinases promiscuously accept γ-modified ATP analogues as cosubstrates and used several ATP analogues as tools for studying protein phosphorylation. Herein, we explore the structural requirements of γ-modified ATP analogues for kinase compatibility. To understand the influence of linker length and ...