European journal of medicinal chemistry

Synthesis of 3-hydroxypyrid-2-ones from furfural for treatment against iron overload and iron deficiency

BS Samant

文献索引：Samant, Bhupesh S. European Journal of Medicinal Chemistry, 2008 , vol. 43, # 9 p. 1978 - 1982

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被引用次数: 8

摘要

Iron overload is the most undesirable since, following saturation of the ferritin and transferrin in the body, deposition of iron can occur and many tissues can be adversely affected, particular toxic effects being degenerative changes in the myocardium, liver and endocrine organs [1]. Certain pathological conditions such as thalassaemia, sickle cell anaemia, idiopathic haemochromatosis and aplastic anaemia are treated by regular blood transfusions [2]. It is commonly found ...