Reagents for the stepwise functionalization of spermidine, homospermidine, and bis (3-aminopropyl) amine

RJ Bergeron, JR Garlich…

文献索引：Bergeron, Raymond J.; Garlich, Joseph R.; Stolowich, Neal J. Journal of Organic Chemistry, 1984 , vol. 49, # 16 p. 2997 - 3001

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被引用次数: 63

摘要

A high-yield synthesis of reagents for the selective mono-, di-, or tri-N-functionalization of the polyamines spermidine, homospermidine, and norspermidine is described. The polyamine protecting groups utilized in these reagents are each easily removable under different conditions: hydrogenolysis, acid, and base. The versatility of these systems was demonstrated by a stepwise deprotection and refunctionalization of the spermidine ...