A high-yield synthesis of reagents for the selective mono-, di-, or tri-N-functionalization of the polyamines spermidine, homospermidine, and norspermidine is described. The polyamine protecting groups utilized in these reagents are each easily removable under different conditions: hydrogenolysis, acid, and base. The versatility of these systems was demonstrated by a stepwise deprotection and refunctionalization of the spermidine ...
[Arimori, Susumu; Bell, Michael L.; Oh, Chan S.; Frimat, Karine A.; James, Tony D. Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 6 p. 803 - 808]
