... J. Heterocyclic Chenr.. ... 3 Chemistry Chart 1 outlines the procedure used to prepare 8x4'- -amino- 1 '-methylbutylamino)-5-(~,~trifluoroethoxy)- -1,6 ... of 22 with diethyl ethoxymethylene malonate yielded 23 which could be selectively methylated at the heterocyclic nitrogen. ...