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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Novel synthesis of 5, 11??dihydro??6H??pyrido [2, 3??b]??[1, 4] benzodiazepin??6??ones and related studies

M Oklobdžija, G Comisso, E Decorte…

文献索引：Oklobdzija; Comisso; Decorte; et al. Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1329 - 1334

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被引用次数: 11

摘要

Abstract 5, 11-Dihydro-6H-pyrido [2, 3-6][1, 4] benzodiazepin-6-one (1), a basic intermediate in the preparation of 11-α-aminoacetyl derivatives with important biological activities, has been obtained by a three-step synthesis starting from easily available isatoic anhydride and anhydro ornithine. Some model cyclisation reactions leading to 5-member ring derivatives 10 and 12 instead of 7-member ring analogues of 1, are reported. Easy transformations of ...

3-(2'-chlorobenzoyl)amino-2-chloropyridine结构式

3-(2'-chloroben...

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2-chloro-N-(2-methoxypyridin-3-yl)benzamide结构式

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2-chloro-N-(2-methoxypyridin-3-yl)benzamide结构式

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2-chloro-N-(2-methoxypyridin-3-yl)benzamide结构式

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2,3-二羟基吡啶结构式

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2-amino-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

2-amino-N-(2-ox...

靛红酸酐结构式

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3-氨基-2-羟基吡啶

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2-amino-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

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2-氯-3-氨基吡啶结构式

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2-(2-bromophenyl)-[1,3]oxazolo[5,4-b]pyridine结构式

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2-溴苯甲酰氯结构式

2-溴苯甲酰氯

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2-(2-bromophenyl)-[1,3]oxazolo[5,4-b]pyridine结构式

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3-(2'-bromobenzoyl)amino-2-chloropyridine结构式

3-(2'-bromobenz...

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2-(2-bromophenyl)-[1,3]oxazolo[5,4-b]pyridine结构式

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3-(2'-bromobenzoyl)amino-2-chloropyridine结构式

3-(2'-bromobenz...

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2-bromo-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

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2-氯-3-氨基吡啶结构式

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2-bromo-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

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2-溴苯甲酰氯

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2-bromo-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

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2-氯-3-氨基吡啶结构式

2-氯-3-氨基吡啶

2-溴苯甲酰氯结构式

2-溴苯甲酰氯

~89%

3-(2'-bromobenzoyl)amino-2-chloropyridine结构式

3-(2'-bromobenz...

3-氨基哌啶-2-酮结构式

3-氨基哌啶-2-酮

靛红酸酐结构式

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2-amino-N-(2-oxopiperidin-3-yl)benzamide结构式

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5-amino-2-piperidino-6-spiro-2'-benzo-1',2',3',8'-tetrahydro-1',3'-oxazin-8'-one结构式

5-amino-2-piper...

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2-amino-N-(2-oxopiperidin-3-yl)benzamide结构式

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DL-鸟氨酸盐酸盐结构式

DL-鸟氨酸盐酸盐

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2-amino-N-(2-oxopiperidin-3-yl)benzamide结构式

2-amino-N-(2-ox...

2,3,4,4a,5,11-hexahydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrochloride结构式

2,3,4,4a,5,11-h...

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2-amino-N-(2-oxopiperidin-3-yl)benzamide结构式

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未登录结构式

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2-amino-N-(2-oxopiperidin-3-yl)benzamide结构式

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ornithine methyl ester结构式

ornithine methy...

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2-amino-N-(2-oxopiperidin-3-yl)benzamide结构式

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3-(2'-chlorobenzoyl)amino-2-chloropyridine结构式

3-(2'-chloroben...

~86%

2-chloro-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

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2-氯-3-氨基吡啶结构式

2-氯-3-氨基吡啶

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2-chloro-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

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邻氯苯甲酰氯结构式

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2-chloro-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

2-chloro-N-(2-o...

2,3-二羟基吡啶结构式

2,3-二羟基吡啶

~13%

3-氨基-2-羟基吡啶结构式

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2-chloro-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

2-chloro-N-(2-o...

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2-chloro-N-(2-sulfanylidene-1H-pyridin-3-yl)benzamide结构式

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2-氯-3-氨基吡啶结构式

2-氯-3-氨基吡啶

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2-chloro-N-(2-sulfanylidene-1H-pyridin-3-yl)benzamide结构式

2-chloro-N-(2-s...

3-(2'-chlorobenzoyl)amino-2-chloropyridine结构式

3-(2'-chloroben...

~%

2-chloro-N-(2-sulfanylidene-1H-pyridin-3-yl)benzamide结构式

2-chloro-N-(2-s...

邻氯苯甲酰氯结构式

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2-chloro-N-(2-sulfanylidene-1H-pyridin-3-yl)benzamide结构式

2-chloro-N-(2-s...

2-chloro-N-(2-oxo-1H-pyridin-3-yl)benzamide结构式

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2-(2-chlorophenyl)-[1,3]thiazolo[5,4-b]pyridine结构式

2-(2-chlorophen...

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2-(2-chlorophenyl)-[1,3]thiazolo[5,4-b]pyridine结构式

2-(2-chlorophen...

3-(2'-chlorobenzoyl)amino-2-chloropyridine结构式

3-(2'-chloroben...

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2-(2-chlorophenyl)-[1,3]thiazolo[5,4-b]pyridine结构式

2-(2-chlorophen...

邻氯苯甲酰氯结构式

邻氯苯甲酰氯

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2-(2-chlorophenyl)-[1,3]thiazolo[5,4-b]pyridine结构式

2-(2-chlorophen...