… Effects of N??Alkyl??1, 2, 4??oxadiazolidine??3, 5??diones and Their Corresponding Synthetic Intermediates N??Alkylhydroxylamines and N??1??Alkyl??3??carbonyl??1?? …
Abstract Herein we report the synthesis and neuroprotective effects of new N-alkyl-1, 2, 4- oxadiazolidine-3, 5-diones and their corresponding synthetic intermediates, N- alkylhydroxylamines and N-1-alkyl-3-carbonyl-1-hydroxyureas, in an in vitro model of ischemia. We found five analogues that protect HT22 cells from death in the concentration range of 1–5 μ M. Because members of the MAP kinase family are known to be key ...
