ChemMedChem

… Effects of N??Alkyl??1, 2, 4??oxadiazolidine??3, 5??diones and Their Corresponding Synthetic Intermediates N??Alkylhydroxylamines and N??1??Alkyl??3??carbonyl??1?? …

AC Biraboneye, S Madonna, P Maher…

Index: Biraboneye, Alain Cesar; Madonna, Sebastien; Maher, Pamela; Kraus, Jean-Louis ChemMedChem, 2010 , vol. 5, # 1 p. 79 - 85

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Citation Number: 7

Abstract

Abstract Herein we report the synthesis and neuroprotective effects of new N-alkyl-1, 2, 4- oxadiazolidine-3, 5-diones and their corresponding synthetic intermediates, N- alkylhydroxylamines and N-1-alkyl-3-carbonyl-1-hydroxyureas, in an in vitro model of ischemia. We found five analogues that protect HT22 cells from death in the concentration range of 1–5 μ M. Because members of the MAP kinase family are known to be key ...